Jay-Z Looking To Sell His Brooklyn Nets Shares?

Word is that the move will take Hov another step closer to becoming a full-fledged sports agent.
By Rob Markman

Jay-Z
Photo: Kevin Mazur/ WireImage

Source: http://www.mtv.com/news/articles/1705311/jay-z-brooklyn-nets-selling-shares.jhtml

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Purple sea urchins evolve in a flash to survive growing acidity

Jackie Sones

Purple urchins have been shown to adapt rather quickly to caustic ocean conditions.

By Tanya Lewis
LiveScience

Mushrooming carbon-dioxide levels are leading to caustic ocean conditions, but some species, like the purple sea urchin, have the ability to adapt to this changing environment, a new study shows.

Researchers grew purple sea urchins?(Strongylocentrotus purpuratus) ? which are echinoderms (a group that also includes sea stars and brittle stars) with spiky protrusions made of calcium carbonate ? in the lab. The invertebrates were grown under conditions mimicking expected future levels of the greenhouse gas carbon dioxide.

In response to high carbon dioxide levels, the urchins showed substantial changes in the proportion of genes involved in regulating their cells' pH (the degree of acidity) and skeletal development.

The oceans are expected to become increasingly acidic this century as carbon dioxide gets pumped into the atmosphere and, ultimately, the seas. The acidity is particularly problematic for organisms that must create shells from calcium carbonate, because the shells are more likely to dissolve under acidic conditions. [Gallery: Stunning Images of Sea Urchins]

"The big unanswered question is, if and how marine organisms will be able to respond to ocean acidification," said Melissa Pespeni, an evolutionary biologist at Indiana University and lead author of the study, published Monday?in the journal Proceedings of the National Academy of Sciences.

Eric Sanford

Beautiful urchin metamorphs.

Pespeni and her colleagues bred adult sea urchins, collected from the Pacific Ocean between central Oregon and Southern California, in tanks exposed to regular carbon-dioxide levels or elevated levels of carbon dioxide forecasted to occur as a result of climate change. The scientists measured the growth and genetic variation of the urchin larvae during their first week of development, a time when the larvae are still free-swimming blobs undergoing major skeletal growth.

The immature urchins showed few visible changes in growth and development, but there were noticeable differences in the abundance of certain genes. The urchins exposed to higher carbon-dioxide levels showed changes in genes involved in promoting growth, producing minerals and keeping pH within a range that's tolerable to them. In comparison, the urchins exposed to current carbon-dioxide levels showed only random genetic variation.

The findings demonstrate that the high-carbon-dioxide environment was exerting natural selection on the urchin larvae: Only the "fittest" ? those with the most advantageous genes ? survived. It was exciting to see that the urchins could adapt, Pespeni told LiveScience.

"If any organism were able to adapt and evolve, it would be the sea urchins, because they live in an environment where they're experiencing daily changes in pH," she said.

The urchins are very long-lived and have more genetic variability than any other species ? including humans, she added. Consequently, the urchins have a broad arsenal for responding to changes in their environment. The findings give scientists hope that organisms like the purple sea urchin might be able to adapt to rising carbon-dioxide levels, but it's unclear whether other organisms will be so flexible.

Moreover, increasing levels of greenhouse gases?is just one of many changes associated with climate change. It would be interesting, Pespeni said, to find out how the urchins would adapt to other stressors, such as temperature.

Despite the ability of some species to adapt to climate change, it is still important to preserve large, robust populations of various animals, Pespeni and her colleagues stressed.

Follow Tanya Lewis on Twitter?and Google+.?Follow us @livescience, Facebook?and Google+. Original article on?LiveScience.com.

Copyright 2013 LiveScience, a TechMediaNetwork company. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

Source: http://feeds.nbcnews.com/c/35002/f/653377/s/2a841ddc/l/0Lscience0Bnbcnews0N0C0Inews0C20A130C0A40C0A90C17672170A0Epurple0Esea0Eurchins0Eevolve0Ein0Ea0Eflash0Eto0Esurvive0Egrowing0Eacidity0Dlite/story01.htm

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Volcanic ash triggers plankton bloom

9 April 2013 Last updated at 20:32 ET By Mark Kinver Environment reporter, BBC News

The 2010 Icelandic volcanic eruption, which disrupted European flights, also had a "significant but short-lived" impact on ocean life, a study shows.

Ash from the Eyjafjallajokull volcano deposited dissolved iron into the North Atlantic, triggering a plankton bloom.

The authors said it was good fortune they were at sea at the time as it provided a unique opportunity to sample the ocean during a volcanic eruption.

The findings appear in the Geophysical Research Letters journal.

In April 2010, the eruption sent an ash plume several kilometres into the atmosphere, causing ash to deposited across up to 570,000 sq km of the North Atlantic Ocean.

The five-week volcanic activity was still ongoing when a team of researchers arrived in the Iceland Basin region aboard a research vessel.

"Our study was unique in the sense that we were the first to undertake sampling at sea of volcanic ash deposition and the chemical and biological effects in the surface ocean," explained lead author Eric Achterberg from the National Oceanography Centre Southampton, UK.

"In addition, we were able to sample the ocean region again a few months after the eruption and observe the changes since the eruption.

"The opportunity to sample during the eruption and also a couple of months after the event allowed us to obtain a unique insight into the effects of the ash deposition on the biology and chemistry of the Iceland Basin."

Iron deficiency

Three years earlier, the team had shown that the production of phytoplankton - microscopic plants that form a key component of marine food chains - was limited by the availability of dissolved iron, which was essential for the tiny plants' growth.

Prof Achterberg told BBC News what the in-situ team was able to record: "Biological experiments showed that the volcanic ash released the iron that stimulated phytoplankton growth.

"The effect of the volcanic ash inputs were nevertheless short-lived as the extra iron supplied by the volcano resulted in rapid biological nitrate removal, thereby causing nitrogen limitation of the phytoplankton population."

So while the additional dissolved iron triggered an earlier-than-usual phytoplankton bloom, as the metal triggered growth in a greater number of phytoplankton cells, the bloom was only 15-20% larger than normal because the growth was limited by the amount of available nitrogen, another vital ingredient required for the organisms to develop.

As well as playing an important role in food chains, phytoplankton also absorb carbon dioxide from the atmosphere.

Oceans are considered to be one of the planet major players in the global carbon cycle, but the carbon uptake in the region where the eruption occurred has limited capacity.

"The high latitude North Atlantic Ocean is a globally important ocean region, as it is a sink for atmospheric carbon dioxide and an area where deep water formation takes place," Prof Achterberg observed.

"A limit to the availability of iron in this region means that the ocean is less efficient in its uptake of atmospheric carbon dioxide."

However during the bloom triggered by the ash deposits from the eruption, the team recorded that it was a shortage of nitrogen that limited the size of the phytoplankton bloom and - as a result - the volume of carbon dioxide uptake.

Prof Achterberg concluded: "The 2010 Eyjafjallajokull eruption therefore resulted in a significant but short lived perturbation to the biogeochemistry of the Iceland Basin."

Source: http://www.bbc.co.uk/news/science-environment-22045941#sa-ns_mchannel=rss&ns_source=PublicRSS20-sa

david wilson

Missing hiker: "I was in a big dream"

ORANGE, Calif. (AP) ? One of two hikers who got lost in the Southern California wilderness last week said Monday she remembers little about her four-day ordeal because she began hallucinating on the first night after the pair finished the three bottles of water they had and darkness fell.

Kyndall Jack, 18, and her friend, Nicolas Cendoya, went missing on March 31 in Cleveland National Forest after wandering off a trail during what they thought would be a short day hike. The pair had picked the hike on the popular Holy Jim Trail almost at random after deciding they wanted to climb to a mountaintop to "touch the clouds," Jack said at a brief news conference.

She said the last thing she remembers is fighting off an animal with Cendoya after darkness fell, but she does not recall how the two got separated or what she did between then and her rescue. She hallucinated she was being eaten by a python, she tried to eat rocks and dirt, and thought that tree twigs were straws from which she could suck water.

"I honestly didn't even know I was missing, I didn't know I was gone, I didn't know anything was going on," she said. "I just thought I was in a big dream."

Jack was plucked by helicopter from a tiny rocky outcropping on a near-vertical cliff Thursday, after searchers followed her cries for help across a canyon and up several dried-up waterfalls. She was severely dehydrated, could not move one arm and complained of shortness of breath and pain in her chest and legs, rescuers said at the time.

Her mouth was so full of dirt the first man to reach her was afraid she would choke if he gave her water.

Cendoya, 19, had been rescued the night before after a volunteer searcher heard him call out from chest-high brush not far from where Jack was found. He was released from the hospital Sunday and the two have since seen each other and tried to make sense of their hallucinations with little luck.

Jack, who was expected to be released late Monday, has frostbite in her left hand and swelling, cuts and bruises on her legs that still make walking difficult.

She sat in a wheelchair and appeared weak during a brief news conference outside the University of Irvine, California Medical Center. The ends of her fingernails were ragged and still coated with dirt and she wore a bandage on one arm, moccasins on her swollen feet and a neon yellow hospital bracelet that said "Fall Risk."

The hike started out well but things quickly went wrong when they left the trail, she recalled.

"We just saw a good place and we were like, 'Oh, we're just going to scale the mountain here," she said.

They realized as darkness fell that they were lost and nowhere near the mountaintop and Cendoya called 911 twice on his dying cellphone.

In the second call, he and Jack can be heard having a tense conversation as the operator tries to determine where exactly they are in the 720-square-mile national forest ? a vast wilderness that runs smack up against the suburban comforts of southeastern Orange County.

"Yeah, we wandered off the trail. We wandered off the trail," Cendoya told the operator. "I don't even know if we'll make it to the morning because we have no water."

At one point, Jack can be heard in the background telling Cendoya there is something moving in the wilderness and at another point, she cries out for help as the operator tells the pair deputies are on foot searching for them.

"We don't hear them, but we screamed and my echo went out for miles," Cendoya says during the nine-minute call.

Jack said Monday that she panicked as the darkness closed in around them. She tried to climb a tree and use her lighter to provide a signal for rescuers, but she dropped it. She thinks she remembers fighting off some type of animal with Cendoya before the two began to slip in and out of consciousness ? but that, too, could have been a dream.

"I started to get like an anxiety attack and I started throwing up and I just lost it. I just went in and out of consciousness after the 911 call," she said.

"We just kept telling each other, 'Don't close your eyes. Don't fall asleep,'" she said.

Jack vaguely remembers "scooting" down a steep embankment ? likely the cliff where she was found ? but she isn't sure when she did that and how she managed to cling to the rocks for so long.

The teen warned other hikers to pack more water and supplies and not stray off the trail.

She also said she'd like to thank two of her rescuers in person: The first reserve sheriff's deputy who reached her and the paramedic who airlifted her to safety in a harness.

Another Orange County reserve sheriff's deputy who participated in the rescue slipped and fell 10 feet, hitting his chest on a rock before falling another 50 feet and hitting his head. He suffered cuts to his head, a punctured lung, broken ribs and other injuries. He was released from intensive care over the weekend and upgraded to fair condition.

Source: http://news.yahoo.com/calif-hiker-4-days-missing-felt-dream-234658888.html

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Anesthetic linked to brain cell death in newborn mice

Apr. 8, 2013 ? Exposure to the anesthetic agent isoflurane increases "programmed cell death" of specific types of cells in the newborn mouse brain, reports a study in the April issue of Anesthesia & Analgesia, official journal of the International Anesthesia Research Society (IARS).

With prolonged exposure, a common inhaled anesthesia eliminates approximately two percent of neurons in the cortex of newborn mice. Although its relevance to anesthesia in human newborns remains to be determined, the study by Dr George K. Istaphanous and colleagues of Cincinnati Children's Hospital Medical Center provides unprecedented detail on the cellular-level effects of anesthetics on the developing brain.

Isoflurane Exposure Increases 'Programmed Death' of Brain Cells

In the study, seven-day-old mice were exposed to isoflurane for several hours. After exposure, sophisticated examinations were performed to assess the extent of isoflurane-induced brain cell death, including the specific types, locations, and functions of brain cells lost.

Isoflurane exposure led to widespread increases programmed cell death, called apoptosis, throughout the brain. Although cell loss was substantially higher after isoflurane exposure, the cell types lost were similar to the cells lost in the apoptosis that is part of normal brain maturation. In both cases, mainly neurons were lost. Neurons are the cells that transmit and store information.

The rate of cell death in the superficial cortex -- the thick outer layer of the brain -- was at least eleven times higher in isoflurane-exposed animals than seen with normal brain maturation. Overall, approximately two percent of cortical neurons were lost after isoflurane exposure. Astrocytes, another major type of cortical brain cells, were less affected by anesthetic exposure.

Relevance to Anesthesia in Human Newborns Is Unclear -- For Now

A growing body of evidence suggests that isoflurane and similar anesthetics may have toxic effects on brain cells in newborn animals and humans. "However, neither the identity of dying cortical cells nor the extent of cortical cell loss has been sufficiently characterized," according to Dr Istaphanous and colleagues.

The new study provides detailed information on the extent and types of brain cell loss resulting from prolonged isoflurane exposure in newborn mice. It's unclear whether the two percent brain cell loss induced in the experiments would lead to any permanent damage -- in previous studies, newborn isoflurane-exposed mice showed no obvious brain damage long after the exposure.

It can't be assumed that isoflurane causes similar patterns of cellular damage in human newborns requiring general anesthesia, Dr Istaphanous and coauthors emphasize. Some studies have linked early-life exposure to anesthesia and surgery to later behavioral and learning abnormalities. Other studies have found no adverse affects on children exposed to anesthetics during vulnerable times of brain development. Further research on the selective nature and molecular mechanisms of isoflurane-induced brain cell death would be needed to determine the relevance of the experimental findings, if any, to human infants undergoing anesthesia.

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The above story is reprinted from materials provided by International Anesthesia Research Society (IARS), via Newswise.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

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Journal Reference:

1. George K. Istaphanous, Christopher G. Ward, Xinyu Nan, Elizabeth A. Hughes, John C. McCann, John J. McAuliffe, Steve C. Danzer, Andreas W. Loepke. Characterization and Quantification of Isoflurane-Induced Developmental Apoptotic Cell Death in Mouse Cerebral Cortex. Anesthesia & Analgesia, 2013; 116 (4): 845 DOI: 10.1213/ANE.0b013e318281e988

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/mind_brain/child_development/~3/R07mepKF7pY/130408152741.htm

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Cabela's to Hire 200 to Staff New Green Bay, Wis., Store

Applications being accepted now, according to general manager Steve Farone.

Cabela?s Green Bay, Wisconsin Store

Cabelas

SIDNEY, Neb. --(Ammoland.com)- Cabela?s Incorporated, the World?s Foremost Outfitter of hunting, fishing and outdoor gear, plans to hire approximately 200 full-time, part-time and seasonal employees to staff its new Green Bay, Wis., store scheduled to open this summer.

Applications are being accepted now and interviews will begin April 22, continuing through April 26.

To apply, visit www.cabelas.jobs, click on ?Apply Now,? then ?United States Jobs,? and select ?Green Bay.? Follow instructions to log in. Applications must be submitted online. Applying does not guarantee an interview.?http://tiny.cc/jdp8uw

Most employees are expected to come from Green Bay and the surrounding area. Typically, Cabela?s attracts applicants with detailed knowledge about the outdoors and an aptitude for customer service.

?Cabela?s is looking for employees who will deliver legendary customer service, and who will be excited about sharing their passion and knowledge of the outdoors with our many loyal customers across the area,? said Steve Farone, general manager of the new store.

The 100,000-square-foot store is located at 1499 Lombardi Ave N near Lambeau Field in the Village of Ashwaubenon in Brown County. It is Cabela?s third Wisconsin store, joining the Richfield and Prairie du Chien locations. In addition to thousands of quality outdoor products, the store will feature a mountain replica, aquarium, indoor archery range, dynamic wildlife displays, Gun Library, Bargain Cave, Deli, Fudge Shop and Sportsman?s Hall of Fame displaying Wisconsin trophy animal mounts.

Currently, Cabela?s operates 43 stores across the United States and Canada. The company has announced plans to open an additional 12 stores by the end of 2014.

www.cabelas.com

About Cabela?s Incorporated
Cabela?s Incorporated, headquartered in Sidney, Nebraska, is a leading specialty retailer, and the world?s largest direct marketer, of hunting, fishing, camping and related outdoor merchandise. Since the Company?s founding in 1961, Cabela?s? has grown to become one of the most well-known outdoor recreation brands in the world, and has long been recognized as the World?s Foremost Outfitter?. Through Cabela?s growing number of retail stores and its well-established direct business, it offers a wide and distinctive selection of high-quality outdoor products at competitive prices while providing superior customer service. Cabela?s also issues the Cabela?s CLUB? Visa credit card, which serves as its primary customer loyalty rewards program. Cabela?s stock is traded on the New York Stock Exchange under the symbol ?CAB?.

Source: http://www.ammoland.com/2013/04/cabelas-to-hire-200-to-staff-new-green-bay-wis-store/

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7-Year-Old Boy Fighting Brain Cancer Scores 69-Yard Touchdown

Sorry, Readability was unable to parse this page for content.

Source: http://www.wildcatnation.net/forum/showthread.php?105833-7-Year-Old-Boy-Fighting-Brain-Cancer-Scores-69-Yard-Touchdown

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Louisville wins NCAA title

ATLANTA (AP) ? Around the Final Four and its host city with journalists from The Associated Press bringing the flavor and details of everything surrounding the games.

___

LOUISVILLE WINS NATIONAL CHAMPIONSHIP

Rick Pitino has history.

The Cardinals' coach became the first to win titles at two different schools, adding to the one he won with Kentucky by leading Louisville to a 82-75 victory over Michigan on Monday night.

Louisville trailed by 12 early in the game, but turned up the pressure on defense, kept up their hot shooting on offense and made enough free throws down the stretch to put away the Wolverines.

Luke Hancock, who led Louisville with 22 points, made two foul shots with 29.8 seconds left for an 80-74 lead. And after Tim Hardaway Jr. scored at the other end for Michigan, Peyton Siva added two more foul shots with 12.9 seconds to go to seal the game.

Trey Burke's 3-pointer in the closing seconds missed everything and went out of bounds, and the Cardinals started to celebrate as Russ Smith was fouled with 2 seconds left.

When the buzzer sounded, the Cardinals rushed to center court and began jumping as fireworks exploded in the Georgia Dome and confetti fell onto the floor.

? Dave Skretta ? http://twitter.com/@APdaveskretta

___

LOUISVILLE'S RALLY

Louisville has stormed back and taken the lead since trailing Michigan by 12 points in the first half of Monday night's championship game.

Michigan led the top-seeded Cardinals 33-21 in the first half. The Cardinals recovered to lead 71-64 with 4:34 remaining ? a 19-point turnaround.

Luke Hancock started the comeback with 16 points in the first half.

? Charles Odum ? http://twitter.com/@CharlesOdum

___

RECORD TURNOUT

The attendance for Monday night's Louisville-Michigan game at the Georgia Dome is 74,326 ? a record for a championship game.

The record may not last long. The 2014 Final Four will be held at Cowboys Stadium in Arlington, Texas. Attendance there could reach 80,000.

? Charles Odum

___

FOUL TROUBLE

Foul trouble is starting to mount for Louisville.

Russ Smith and Peyton Siva, the Cardinals' starting guards, each picked up their third foul early in the second half, along with Luke Hancock, who had been hot from the 3-point line.

The foul trouble in the backcourt is especially troublesome for Louisville because of the injury sustained by Kevin Ware, who had been providing valuable minutes off the bench.

Ware broke his leg in the regional finals against Duke.

The Wolverines were in better shape, with only forward Mitch McGary in foul trouble. The big forward picked up his fourth with 9:11 left in the game.

? Dave Skretta

___

HOT SHOOTING

So much for that theory about poor shooting in domes.

Michigan and Louisville aren't having any trouble. The teams combined to start the second half 5 of 6 from the field.

The Wolverines took a 38-37 lead into halftime Monday night thanks in part to shooting 50 percent from the field, and 6 of 11 from beyond the arc. Spike Albrecht helped, of course, with his 6-for-7 half and by going 4 for 4 from deep.

The Cardinals aren't doing shabby, either. They were hitting at a 46-percent clip and were 5 of 8 from beyond the arc, led by a 4-for-4 effort from Luke Hancock.

There's long been a belief that shooting in domes is more difficult because depth perception is thrown off by the spacious surroundings. That hasn't been the case tonight.

? Dave Skretta ? http://twitter.com/@APdaveskretta

___

HALFTIME ? MICHIGAN LEADING

It's halftime at the national championship game and Michigan is 20 minutes away from only its second national championship.

Freshman Spike Albrecht is the surprise scoring leader with 17 points as Michigan leads Louisville 38-37 at halftime of Monday night's championship game. Michigan won its only title in 1989.

Michigan, the No. 4 seed, is trying to upset Louisville, the No. 1 seed. Luke Hancock has 16 points for Louisville, which made a late charge to lead 37-36 before Michigan's Glenn Robinson III sank two free throws with 2.5 seconds remaining.

Michigan star Trey Burke scored the first five points on a jumper and 3-pointer and had seven points less than 3 minutes into the game, matching his total from the Wolverines' semifinal win over Syracuse.

? Charles Odum ? http://twitter.com/CharlesOdum

___

GETTING SPIKED!

Louisville is getting Spiked in the NCAA finals.

As in, Spike Albrecht.

The freshman guard for Michigan has nearly outscored the Cardinals by himself ? he had 17 points as the Wolverines raced to a 33-21 lead late in the first half.

Albrecht was 4 for 4 from beyond the arc, running his NCAA tournament to 9 for 9 and matching Sam Cassell of Florida State (1993) for the most 3-pointers without a miss in tourney history.

Albrecht came into the game averaging about 2 points, with nine made 3s all season. His season high had been just seven points.

Late in the half, he got the ball on the wing and pumped faked from beyond the arc, not only bringing his defender off his feet but also about 50,000 fans. Albrecht wisely passed the ball away, but got it back moments later and converted on a nifty driving layup.

He furiously punched the air as Louisville called timeout.

? Dave Skretta

___

WEBBER SIGHTING

Former five-time NBA All-Star Chris Webber showed up at the Georgia Dome just about the time Michigan's starting lineup was being introduced before the Wolverines squared off against Louisville in Monday's night's national championship game.

CBS-TV showed Webber arriving at the Georgia Dome and exiting his car minutes before the game. He was wearing a UM hat.

Webber played on Michigan's 1992 and 1993 Final Four teams but a federal investigation revealed that a booster gave Webber and three non-Fab Five players more than $600,000 while they were student-athletes. The NCAA forced the school to dissociate from them until this year. The dissociation officially ends in May.

? Charles Odum

___

CLEAN PLAY

There haven't been many whistles blown early on in the championship game.

That's a good thing, too.

After a season in which basketball often resembled wrestling, and in which officials often stole the headlines, it was Michigan and Louisville on center stage at the Georgia Dome.

Only two fouls had been called in the first 7 minutes, 11 seconds, as the teams got into an up-and-down affair that finally looked the way basketball was meant to be played.

Both teams were shooting it well, too. Michigan started off 7 of 11 from the field, while Louisville was 5 for 11 as the second media timeout neared.

? Dave Skretta

___

VENUS WILLAMS

Venus Williams' pick is looking pretty good.

The tennis star is using her mother's home state as a good reason to cheer for Michigan against Louisville. The Wolverines are up 38-37 at the half.

Williams said she hasn't watched much of the NCAA tournament but is pulling for Michigan because her mother was born in Saginaw, Mich.

"I'm going with her hometown," Williams said before the game. She is in Atlanta on Monday to promote her athletic clothing line, EleVen.

? Jonathan Landrum ?http://twitter.com/@MrLandrum31

___

SANDY HOOK

Police Chief Michael Kehoe and some of the other officers from Newton, Conn., who responded to the shooting at Sandy Hook Elementary School were honored during a timeout in the first half at the Final Four.

The crowd erupted when the officers, dressed in their uniforms, were shown on the video board hanging over the court and on the screens at each end of the Georgia Dome.

Twenty children and six adults were killed in the shooting last December.

? Dave Skretta

___

WARE CHEERS

Injured Louisville guard Kevin Ware followed his same pregame routine as in the Cardinals' semifinal win over Wichita State.

Ware, on crutches after having surgery to repair his broken right leg, again was cheered when he took his seat by the Louisville bench. Wearing his white No. 5 jersey, Ware sat beside the elevated court, facing the action, where he could prop up his injured leg on another chair. He stood at the end of Saturday's semifinal win over Wichita State and even shocked his teammates by joining a late-game huddle.

His teammates again wore T-shirts over their jerseys in pregame warmups with the words "Ri5e to the Occasion." A fan raised a sign which read "Rise for 5."

Ware played at Rockdale County High School, about 30 miles east of Atlanta.

? Charles Odum

___

MICHIGAN's HOMECOURT

Michigan ought to have a homecourt advantage over Louisville on Monday night.

The maple floor that the teams are playing on in the Georgia Dome was made by Connor Sport Court International at its plant in Amasa, Mich., and the lumber for it came from Timber Products Company, which is based in Munising, Mich.

The court is made up of 4-by-7 foot pieces that were sent by truck to Atlanta, where they were fitted together on an elevated platform in time for the Final Four.

Connor Sport Court also made the court for the women's Final Four in New Orleans.

? Dave Skretta

___

MAYWEATHER'S PICK

Floyd Mayweather Jr. won't know until halftime which team he'll pick to win the national basketball championship.

Once the undefeated boxing champion figures it out, he is expecting to place a $50,000 bet toward either Michigan or Louisville in the NCAA title game on Monday night. He thinks the Wolverines have a strong chance to come away with the crown if they're able to sustain an early lead against the Cardinals.gg

"I think that if Michigan gets a lead like that, it's going to be kind of hard to come back," said Mayweather, who is an avid sports fan and often bets on games. He probably should wait as long as he can: He had Indiana winning it all in his bracket.

Mayweather was in Atlanta to promote his upcoming fight against Robert Guerrero on May 4 in Las Vegas.

? Jonathan Landrum

___

TRAVIS TRITT

Country musician Travis Tritt has quite the task ahead of him when he performs the national anthem prior to Monday night's national championship between Michigan and Louisville.

The Georgia native will be following a virtuoso performance by the Ebenezer Baptist Church Choir before Saturday night's national semifinals, a rendition that drew almost universal praise from fans, the media and across social media platforms.

Tritt is no stranger to big sporting events. The two-time Grammy Award-winner has performed at two Super Bowls, a World Series and the 1996 Atlanta Olympics, and will be performing for the 15th time during Kentucky Derby festivities next month in Louisville, Ky.

? Dave Skretta

___

TICKET PRICES

Fans waiting until the last minute to buy NCAA championship game tickets are paying a steep price.

The average price for Monday night's game had soared to $720, according to TiqIQ.com, which tracks ticket trends. The company says that is a 140-percent increase over last year's final between Kentucky and Kansas in New Orleans.

At Ticketstub.com, prices for Monday night's game were starting at $330 about three hours before the game.

? Charles Odum

___

MICHIGAN'S FAB FIVE

One unanswered question at the Final Four: Will there be a reunion of Michigan's Fab Five?

Twenty years ago, the brash group of Michigan youngsters lost to North Carolina in the NCAA title game. This is Michigan's first trip back to the championship game.

Chris Webber's whereabouts are causing the most commotion. Jalen Rose went on a Grantland.com podcast and encouraged Webber to join him and other Fab Five players at Monday night's title game against Louisville, but it's not clear whether that will happen.

Michigan has been recovering from the fallout after a federal investigation revealed that a booster gave Webber and three non-Fab Five players more than $600,000 while they were student-athletes. The NCAA forced the school to dissociate from them until this year. The dissociation officially ends in May.

On Saturday, Webber tweeted "It's Your Time Now!" ? along with a picture of current Michigan players Trey Burke, Tim Hardaway Jr. and Glenn Robinson III.

? Noah Trister ? http://twitter.com/@noahtrister

___

HAIL TO THE VICTORS

Michigan coach John Beilein attended the Final Four in 1989, when the Wolverines last won a national championship, and remembers one thing sticking out in his mind:

"Hail! to the victors valiant

Hail! to the conqu'ring heroes

Hail! Hail! to Michigan

The leaders and best!"

"I heard 'The Victors.' I heard the best fight song in the world," said Beilein, who was then a coach at Division II Le Moyne, and was attending the Final Four in Seattle with his wife, Kathleen.

"Kathleen and I looked at each other and said, 'This is the best fight song I have ever heard," Beilein recalled this week. "That's why it's so eerie to hear it today, that it ended up being my destination."

? Dave Skretta

____

NCAA Finals Watch follows the Final Four games and all the activities surrounding the event as seen by journalists from The Associated Press from across Atlanta. It will be updated throughout the day with breaking news and other items of interest. Follow AP reporters on Twitter where available.

Source: http://news.yahoo.com/finals-watch-louisville-wins-national-title-034735022--spt.html

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Video: Schumer & McCain: Let's have debate on gun control (cbsnews)

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Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/297324179?client_source=feed&format=rss

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[Q] Android won't boot after CM 10 upgrade but WEB OS works.

---

Android in boot loop after trying to go from CM 9 to CM 10,goes from boot selection to cyanogenmod loading screen then back to boot selection.Can boot into WEB OS, CWM but not TWRP were my backup was.If I start in USB mode the TP wont show in My Computer but shows in Devices and Printers on my computer so uninstaller wont work.I can boot WEB OS and go into USB mode and it shows in MY Computer and I can access files but uninstaller wont work from there.Downloaded CM 10 again thru web os and tried CWM update but no luck.IT may stem from a TWRP update I did a while back,couldnt do goomanger updates after that.Please help.

Source: http://forum.xda-developers.com/showthread.php?t=2223719&goto=newpost

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China kills market birds as flu found in pigeons

Workers in protective clothing chat during a culling operation as authorities detected the new bird flu strain in pigeons being sold for meat at a wholesale market in Shanghai on Friday April 5, 2013. China announced a sixth death from a new bird flu strain Friday, while authorities carried out the slaughter of all poultry at a Shanghai market where the virus was detected in pigeons being sold for meat. (AP Photo) CHINA OUT

Workers in protective clothing chat during a culling operation as authorities detected the new bird flu strain in pigeons being sold for meat at a wholesale market in Shanghai on Friday April 5, 2013. China announced a sixth death from a new bird flu strain Friday, while authorities carried out the slaughter of all poultry at a Shanghai market where the virus was detected in pigeons being sold for meat. (AP Photo) CHINA OUT

A Chinese policeman wears a mask as he guards an access to a wholesale market where authorities are culling poultry after the new bird flu strain was detected there in pigeons being sold for meat in Shanghai on Friday April 5, 2013. China announced a sixth death from a new bird flu strain Friday, while authorities carried out the slaughter of all poultry at a Shanghai market where the virus was detected in pigeons being sold for meat. (AP Photo) CHINA OUT

Workers in protective clothing move bags out from a wholesale market during a culling operation as authorities detected a new bird flu strain in pigeons being sold for meat at the market in Shanghai, China, Friday April 5, 2013. China announced a sixth death from a new bird flu strain Friday, while authorities carried out the slaughter of all poultry at a Shanghai market where the virus was detected in pigeons being sold for meat. (AP Photo) CHINA OUT

A vender waits for the customers at a poultry market in Shanghai, China on Friday, April 5, 2013. China announced Friday a sixth death from a new bird flu strain while authorities carried out the slaughter of all poultry at a Shanghai market where the virus was detected in pigeons being sold for meat. (AP Photo/Eugene Hoshiko)

A worker catches a live chicken at a poultry market in Shanghai, China on Friday, April 5, 2013. China announced a sixth death from the new bird flu H7N9 strain Friday, while authorities in Shanghai halted the sale of live fowl and slaughtered all poultry at a market where the virus was detected in pigeons being sold for meat. The first cases were announced Sunday. (AP Photo)

BEIJING (AP) ? China announced a sixth death from a new bird flu strain Friday, while authorities in Shanghai halted the sale of live fowl and slaughtered all poultry at a market where the virus was detected in pigeons being sold for meat.

The mass bird killing is the first so far as the Chinese government responds to the H7N9 strain of bird flu, which has sickened 16 people, many critically, along the eastern seaboard in its first known infections of people. The first cases were announced Sunday, while two more were reported Friday, both retirees who were seriously ill.

Health officials believe people are contracting the virus through direct contact with infected fowl and say there has been no evidence so far that the virus is spreading easily between people. However, scientists are watching closely to see if the flu poses a substantial risk to public health or could potentially spark a global pandemic.

The Agriculture Ministry confirmed late Thursday that the H7N9 virus had been detected in live pigeons on sale at a produce market in Shanghai. The killing of birds at the Huhuai market in Shanghai started Thursday night after the city's agricultural committee ordered it in a notice also posted on its website.

State media on Friday ran pictures of animal health officials in protective overalls and masks working through the night at the market, taking notes as they stood over piles of poultry carcasses in plastic bags. The area was guarded by police and cordoned off with plastic tape.

Experts urged Chinese health authorities to keep testing healthy birds, saying the H7N9 virus can infect birds without causing them to become ill, making it harder to detect than the H5N1 bird flu virus that is more familiar to Asian countries. H5N1 set off warnings when it began ravaging poultry across Asia in 2003 and has since killed 360 people worldwide, mostly after close contact with infected birds.

"In the past usually you would see chickens dying before any infections occurred in humans, but this time we've seen that many species of poultry actually have no apparent problems, so that makes it difficult because you lose this natural warning sign," said David Hui, an infectious diseases expert at the Chinese University of Hong Kong.

The city of Shanghai also announced a suspension of the sale of live poultry starting Saturday, city spokesman Xu Wei said at a news conference.

Pigeon is a common type of poultry in Chinese cuisine and the birds are sold live in markets around the country. Chinese also raise pigeons as pets, but those tend to be a different type.

Hui said the pigeons were probably infected by wild or migratory birds, whose droppings can carry viruses. He said they were likely not the only species of poultry to be carrying the virus.

While health officials caution that there are no indications the virus can be transmitted from one person to another, scientists who have studied its genetic sequence said this week that the virus may have recently mutated into a form that spreads more easily to other animals, potentially posing a bigger threat to humans.

The latest death from the virus confirmed by the government Friday was a 64-year-old farmer in the eastern city of Huzhou. Authorities said Thursday the virus also killed a 48-year-old man who transported poultry for a living and a 52-year-old woman, both in Shanghai. Several among the infected are believed to have had direct contact with fowl.

Guidelines issued Wednesday by the national health agency identify butchers, breeders and sellers of poultry, and those in the meat processing industry as at higher risk.

Experts identified the first cases on Sunday. Some of the 16 confirmed cases fell ill several weeks ago but only now are being classified as having H7N9. The official Xinhua News Agency said six cases have been confirmed in Shanghai, six in Jiangsu, three in Zhejiang and one in Anhui.

___

Associated Press researcher Fu Ting contributed to this report from Shanghai.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/bbd825583c8542898e6fa7d440b9febc/Article_2013-04-05-China-Bird%20Flu/id-aeaa9e2b5fed42f1812d573415793791

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NASA chooses all-sky planet hunter, neutron star watcher for liftoff in 2017

MIT

An artist's conception shows the Transiting Exoplanet Survey Satellite, or TESS, in space. (Planets not to scale.)

By Alan Boyle, Science Editor, NBC News

NASA has selected two new space missions for launch in 2017:?a satellite that can scan the entire sky for exoplanets and a space station experiment that can monitor cosmic X-ray emissions. The Transiting Exoplanet Survey Satellite (TESS) and the Neutron-star Interior Composition Explorer (NICER) won out at the end of a selection process that took more than two years.

"With these missions we will learn about the most extreme states of matter by studying neutron stars, and we will identify many nearby star systems with rocky planets in the habitable zone for further study by telescopes such as the James Webb Space Telescope," John Grunsfeld, NASA's associate administrator for science, said in a statement Friday.

Under the terms of NASA's Explorer Program, the TESS mission will be budgeted at no more than $200 million, and NICER's mission costs will be capped at $55 million. Those price tags exclude the cost of the launch vehicle.

---

Planet hunter
TESS is designed to follow up on NASA's Kepler mission, which is surveying a patch of sky in the constellations Cygnus and Lyra for extrasolar planets. Like Kepler, TESS would detect other worlds by looking for the faint dips in starlight as they make regular transits across their parent suns. TESS' array of wide-angle cameras would take in much more territory, however.

"TESS will carry out the first space-borne all-sky transit survey, covering 400 times as much sky as any previous mission," principal investigator George Ricker, a research scientist at the Massachusetts Institute of Technology's Kavli Institute for Astrophysics and Space Research, said in a statement. "It will identify thousands of new planets in the solar neighborhood, with a special focus on planets comparable in size to the Earth."

The mission's scientists say it will be possible to study the masses, sizes, densities, orbits and atmospheres of a wide range of planets, including a sampling of the rocky worlds in the habitable zones of nearby planetary systems. "The selection of TESS has just accelerated our chances of finding life on another planet within the next decade," said MIT planetary scientist Sara Seager.

TESS won out over another planet-hunting mission designed to study alien atmospheres, known as the?Fast Infrared Exoplanet Spectroscopy Survey Explorer or FINESSE.

NASA

An artist's conception shows the boxlike NICER array attached to the International Space Station.

Star watcher
NICER is an instrument that's about the size of a college dorm-room refrigerator, equipped with an array of 56 telescopes that can measure the variability of cosmic X-ray sources ? a method known as X-ray timing.?It's designed to explore the exotic states of matter within neutron stars and reveal their interior and surface compositions. The device can also monitor the stars' positions as a navigational aid.

"Our technology demonstration will establish the viability of spacecraft navigation using neutron stars, while the same instrument gives scientists an important new tool with which to better understand these stars that can serve as navigation beacons," principal investigator Keith Gendreau of NASA's Goddard Space Flight Center said in a news release.

NICER would be brought to the International Space Station aboard a Japanese HTV robotic transport craft or a SpaceX Dragon cargo capsule, and attached to the station's exterior.

NASA's Explorer Program is designed to provide frequent, low-cost access to space for astrophysics and solar science missions. The program has launched more than 90 missions, starting with Explorer 1 in 1958. The most recent Explorer mission to be launched was the Nuclear Spectroscopic Telescope Array, or NuSTAR. The next one is the?Interface Region Imaging Spectrograph, or IRIS, due for launch sometime in the next couple of months.

More about exoplanets:

---

Alan Boyle is NBCNews.com's science editor. Connect with the Cosmic Log community by "liking" the log's?Facebook page, following?@b0yle on Twitter?and adding the?Cosmic Log page?to your Google+ presence. To keep up with Cosmic Log as well as NBCNews.com's other stories about science and space, sign up for the Tech & Science newsletter, delivered to your email in-box every weekday. You can also check out?"The Case for Pluto,"?my book about the controversial dwarf planet and the search for new worlds.

Source: http://feeds.nbcnews.com/c/35002/f/653377/s/2a6919f3/l/0Lcosmiclog0Bnbcnews0N0C0Inews0C20A130C0A40C0A60C176233720Enasa0Echooses0Eall0Esky0Eplanet0Ehunter0Eneutron0Estar0Ewatcher0Efor0Eliftoff0Ein0E20A170Dlite/story01.htm

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Union goalie Troy Grosenick signs with San Jose, per report

Grosenick, who has been a part of the Dutchmen's back-to-back NCAA Tournament berths, reportedly forgoes his senior season.

According to our own Andy Johnson and Ken Schott of the Daily Gazette in Schenectady, New York, Union junior goaltender Troy Grosenick will forego his senior season to sign a professional contract with the San Jose Sharks.

He is the third undrafted free agent reported Friday to sign with San Jose. Previously, Minnesota State forward Eriah Hayes and Colorado College forward Rylan Schwartz signed following the expiration of their college eligibility.

After making a single start his freshman year, Grosenick more than made up for it his last two years. Troy posted 5 shutouts as a sophomore and had a 1.65 GAA and .936 save percentage. He was named a Hobey Baker finalist for his individual efforts. Team-wise, Grosenick led the Dutchmen to their first-ever Frozen Four appearance.

This past season wasn't as good individually - Grosenick finished with a 2.12 GAA and .926 save percentage - yet Union was successful as a team. They came on strong towards the end of the season and won their second straight ECAC conference tournament title. Although the Dutchmen routed Boston College 5-1, they fell to conference rival Quinnipiac in the East Region final.

--

For more SB Nation College Hockey coverage, follow us on Twitter @sbncollegepuck and like us on Facebook.

? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Source: http://www.westerncollegehockeyblog.com/2013/4/5/4188980/2013-early-departures-union-goalie-troy-grosenick-signs-with-san-jose-per-report

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HP Chairman Lane resigns, Whitworth takes over for now

By Poornima Gupta

SAN FRANCISCO (Reuters) - Hewlett-Packard Co Chairman Ray Lane, who has come under fire from shareholders for his role in the acquisition of software company Autonomy Plc, has relinquished his post in the No.1 personal computer maker's latest board shake-up.

Two other directors left as HP, which has gone through several board upheavals in the past decade, said director and activist investor Ralph Whitworth will serve as interim chairman until Lane's replacement is found.

HP is also seeking two to three new board members, the company said on Thursday.

The changes come weeks after Lane, a Kleiner Perkins managing partner who will remain an HP director, narrowly won reelection at HP's annual shareholders' meeting with less than 60 percent of voting shares compared with 96 percent a year ago.

Two other directors who kept their seats with narrow margins, G. Kennedy Thompson and John Hammergren, will leave the board, and the company will look for two to three new, independent replacements.

Lane is one of the most prominent casualties of an acquisition that has incensed investors, who have criticized the company for paying $11 billion for Autonomy and for failing to conduct proper due diligence. HP eventually took a multi-billion dollar writedown on the asset's value.

"After reflecting on the stockholder vote last month, I've decided to step down as executive chairman to reduce any distraction from HP's ongoing turnaround," Lane said in statement. "Since I joined HP's board a little over two years ago, I've been committed to board evolution to ensure our turnaround and future success."

The Autonomy deal capped a tumultuous decade for the company that included the "pretexting" scandal of 2006, which led to the resignation of then-chairwoman Patricia Dunn.

Four directors left HP in early 2011 following the ouster of former CEO Mark Hurd in 2010. In late 2011 Whitworth joined the board and director Whitman became CEO.

Whitworth, who runs activist hedge fund Relational Investors LLC, had said at HP annual shareholders' meeting in March to prepare for an "evolution" of the board.

SHAREHOLDERS WIN

Influential proxy firms ISS and Glass Lewis had recommended that investors vote against a roster of directors at HP.

"The board needs to embrace long-term shareholders in the selection of directors who can restore confidence in the audit process, lend the necessary skepticism to quick-fix acquisitions, and bring experience that can help HP nurture its workplace culture of innovation," shareholder CtW Investment Group said in a statement.

Calpers, the largest public pension fund in the U.S. with about $256 billion in assets, said in a statement that it welcomed the resignation of Lane and the departure of two directors.

"It is time to move beyond the recent failures at HP and bring fresh talent to the boardroom. HP needs a board which is unencumbered and will provide rigorous oversight of all decisions, including reviewing the auditor," said Anne Simpson, Calpers senior portfolio manager and director of global governance.

Hammergren and Thompson, who received 54 percent and 55 percent of shareholder votes respectively, will exit after a board meeting scheduled for May, HP said.

Another director, Rajiv Gupta, will remain on the board but will no longer be a lead independent director. He will replace Thompson as chairman of audit committee.

The upheaval comes as HP and CEO Meg Whitman are undertaking a multi-year turnaround to stimulate growth at the company, which was once synonymous with Silicon Valley but has since stagnated as its personal computer and printer business declined.

She has asked investors to be patient while the company undertakes layoffs and cost cuts and expands into areas with longer-term potential, such as enterprise computing services.

HP shares fell to $22.10 in after-hours trade, from their close of $22.30 on the New York Stock Exchange on Thursday.

(Reporting by Edwin Chan; additional reporting by Sakthi Prasad; Editing by Gary Hill and Richard Chang)

Source: http://news.yahoo.com/hp-chairman-lane-resigns-whitworth-takes-over-now-001523701--finance.html

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A gay-marriage parade in the Senate

A supporter of same-sex marriage wears a rainbow flag in front of the U.S. Supreme Court on Tuesday (Andrew Harrer / Bloomberg)

Without question, last week was a great moment in gay history. The Supreme Court heard arguments in two cases that speak to the civil rights of same-sex couples. But this week wasn?t bad, either.

In a near-daily parade, six senators expressed public support for marriage equality. On Monday, Sen. Bob Casey (D-Pa.) said yes. Tuesday was a double-header, with Sens. Tom Carper (D-Del.) and Mark Kirk (R-Ill.). Wednesday must have been soul-searching day because on Thursday, Sen. Bill Nelson (D-Fla.) came out for same-sex marriage. And today, Sens. Joe Donnelly (D-Ind.) and Heidi Heitkamp (D-N.D.), both elected in 2012, said ?I do? to gay nups. Sen. Rob Portman (R-Ohio) got the ball rolling with his stunning announcement of support last month.

For the first time, a majority of the U.S. Senate supports marriage equality. To be specific, there are now 53 senators, including two Republicans, standing up for the dignity of same-sex couples and their families and who favor ensuring that equal protection under the law applies to them. They hail from red states and blue states. They are newly elected, reelected or up for reelection in 2014.

Equality for lesbian, gay, bisexual and transgender (LGBT) Americans is inevitable. And Carper, Casey, Donnelly, Heitkamp, Kirk and Nelson should be hailed for hastening the process.

Follow Jonathan Capehart on Twitter.

Source: http://www.washingtonpost.com/blogs/post-partisan/wp/2013/04/05/a-gay-marriage-parade-in-the-senate/

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Amid the haze of new Colorado legal pot rules, a small victory for ...

• 

Lost in the haze around Colorado?s historic vote to legalize marijuana is that when voters passed Amendment 64 in November, they also legalized hemp, marijuana?s long-suffering cousin.

Smoking hemp doesn?t get you high, but growing it, possessing it or selling it carries the same federal penalties as marijuana.

Colorado lawmakers are struggling with how to regulate this now-legal crop in a way that won?t trigger a federal crackdown on those who pioneer this new industry.

As a result, farmers are finding they have a lot in common with those who want to sell joints and pot brownies at recreational marijuana retail stores. Federal prohibition affects more aspects of business life than many newcomers to these industries imagine. It can prevent businesses from opening checking account with funds earned through federally prohibited activities, or prevent them from claiming pot-business deductions on federal tax returns.

?It?s a headache,? said Leland Swenson, the executive vice president of government relations for the Rocky Mountain Farmers Union. ?And it doesn?t need to be.?

While much attention this week is focused on recreational pot issues ? like a controversial ?driving while stoned? bill which passed the state House Tuesday, and yet-to-be-decided issues like which agency will oversee regulating the industry and how its taxing system will be structured ? farmers are grappling with their own unanswered questions around hemp.

The biggest unknown is the potential blowback they face if the feds make an issue out of hemp farming, Swenson said. Hemp farmers stand to lose their commodity titles that support the prices of other crops in their fields, like wheat and corn. They could be denied federally backed crop insurance. And they could lose their ability to participate in federally administered conservation programs.

?The real problem that many producers face is that it?s still illegal federally,? Swenson said.

RMFU wrote about these concerns to U.S. Department of Agriculture, asking if there would be a ?negative impact? on farmers who take advantage of Colorado?s new law to plant some hemp.

?We haven?t heard back yet,? he said.

The United States is the only industrialized country without a hemp industry, even though hemp is recognized as a legitimate crop under NAFTA and GATT. Despite its federal prohibition, it?s legal to import hemp from places like Canada and France, which provide raw material for U.S. companies making such things as carpet, automotive parts and even concrete, which hemp can be used to strengthen. The annual North American hemp market is estimated to be at least $300 million.

Hemp is attractive to farmers for a number of reasons. It?s well-suited to growing in Colorado?s semi-arid climate and, compared to other crops, yields a higher return per acre. Because of its illegality, there are few studies of the costs and benefits of growing hemp, but a 1997 USDA study shows that hemp is more profitable per acre that every other common crop except tobacco.

?From a producer standpoint, there?s a lot of interest,? Swenson said, ?but there are also a lot of questions that they?d like to have answered.?

The process of getting answers may start soon. Colorado lawmakers must adopt industry-wide regulations for recreational marijuana ? and industrial hemp ? by the end of the legislative session, which is scheduled to adjourn on May 8.

Follow Greg on Twitter

Content created by The Daily Caller News Foundation is available without charge to any eligible news publisher that can provide a large audience. For licensing opportunities of our original content, please contact?licensing@dailycallernewsfoundation.org.

?

Source: http://dailycaller.com/2013/04/04/amid-the-haze-of-new-colorado-legal-pot-rules-a-small-victory-for-hemp/

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Mitochondrial metabolic regulator SIRT4 guards against DNA damage

Friday, April 5, 2013

Healthy cells don't just happen. As they grow and divide, they need checks and balances to ensure they function properly while adapting to changing conditions around them.

Researchers studying a set of proteins that regulate physiology, caloric restriction and aging have discovered another important role that one of them plays. SIRT4, one of seven sirtuin proteins, is known for controlling fuel usage from its post in the mitochondria, the cell's energy source. It responds to stressful changes in the availability of nutrients for the cell.

New research reveals that SIRT4 is also extremely sensitive to a different form of stress: DNA damage. This unsuspected response by the metabolic checkpoint means SIRT4 doubles as a sentry guarding against cancer, which is spurred by genetic abnormalities.

Sirtuins have become familiar for their connection to longevity and to resveratrol, the red-wine compound that activates SIRT1, but less attention has been focused on SIRT3, SIRT 4 and SIRT5, all of which are found in mitochondria. Marcia Haigis, HMS associate professor of cell biology, led a team that has uncovered SIRT4 as an important player in the DNA damage response pathway, coordinating a sequence of events that normally result[s] in tumor suppression. They published their results April 4 in Cancer Cell.

"When we started studying SIRT4, we were focused only on its metabolic role, looking for functions related to diabetes and obesity," said Haigis. "What we found, to our surprise, was that SIRT4 was responsive to DNA damage, so that led us to investigate the metabolic response to DNA damage and how SIRT4 controls the metabolic response to genotoxic stress."

To see how SIRT4 normally functions, Haigis and her colleagues induced DNA damage by exposing cells in a lab dish to ultraviolet light. This damage triggered a halt in glutamine metabolism, limiting the amount of nutrients the cell could use as it goes through a cycle of division and growth.

Blocking the cell cycle at this juncture is important. If cell growth after DNA damage goes unchecked, proliferation of impaired cells can lead to cancer. When SIRT4 works properly, this chain of events is broken before bad cells and their abnormal genes multiply. SIRT4 blocks glutamine metabolism, arrests the cell cycle and suppresses tumor formation.

The scientists tested this SIRT4 response in mice. Bred to lack the gene that encodes the SIRT4 protein but otherwise normal, the mice spontaneously developed lung cancer by 15 months.

"When SIRT4 is missing, you don't have this metabolic checkpoint involving glutamine, which is important because glutamine is an amino acid required for proliferation in the cell," Haigis said. "Without SIRT4, the cell keeps dividing even in the face of DNA damage, so the cell accumulates more damage."

The scientists also analyzed data showing SIRT4 gene expression levels are low in several human cancers, including small-cell lung carcinoma, gastric cancer, bladder carcinoma, breast cancer and leukemia.

While they cannot say if SIRT4 loss alone will initiate cancer, its absence appears to create an environment in which tumor cells survive and grow.

"Our findings suggest that SIRT4 may be a potential target against tumors," they conclude.

###

Harvard Medical School: http://hms.harvard.edu

Thanks to Harvard Medical School for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

This press release has been viewed 45 time(s).

Source: http://www.labspaces.net/127612/Mitochondrial_metabolic_regulator_SIRT__guards_against_DNA_damage

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What would Reagan do? (CNN)

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Phaedra Parks: "This Pregnancy Is Going Great"

Set to star in The Real Housewives of Atlanta spin-off Rich People?s Problems, Phaedra Parks is one busy expectant mama! Already mom to 2-year-old son Ayden, Phaedra and husband?Apollo Nida expect their second son in May.

The reality star opens up to Celebrity Baby Scoop about balancing her career and family life, her workout DVDs, and her husband?s official role and baby namer this time around.?She goes on to talk about maintaining an eco-friendly household and her second pregnancy that is ?going really great.?

CBS: How is your second pregnancy going? Do you have any baby names in mind?

PP: ?The pregnancy is going great, it?s going really good. I don?t have any baby names in mind as my husband will be giving him his name. I don?t know if he?s actually decided on a name yet.?

CBS: Tell us about your son Ayden. How old is he and what is he into?

PP: ?Ayden is 2-years-old and he loves to swim and play instruments. The instruments that he loves right now are the bass guitar and the drums.?

CBS: Is he excited to be a big brother?

PP: ?He says he is, but I?m not sure if he really comprehends that it will be another person living in our house on a daily basis. I am not sure if he thinks the baby is just going to be visiting for a short time. He?s very excited. He wanted a sister, but I?m having a son.?

CBS: What can fans of Real Housewives of Atlanta expect to see in upcoming episodes?

PP: ?I guess more of the same drama we?ve seen all season.?

CBS: Tell us about your workout DVD Phine Body. What inspired you to do the DVD?

PP: ?We?ve got two DVDs. The first DVD focuses on the lower body and the second one focuses on the complete body workout. I?m actually getting ready to shoot a prenatal workout DVD in about three-and-a-half weeks to add to our collection. I?m really excited about that. If we shoot it in April, it should be up and available for rollout no later than the summer months. It will come out early summer or mid-summer, maybe in June.

I was inspired to do the workout DVDs because I am a mom and a working woman. When I was pregnant with Ayden, I really tried to workout a lot. A lot of times, I don?t have time to go to the gym because I am a professional woman and a mom who has to do all the household stuff that moms have to do.

I wanted the ability to workout at home and I wanted something that was fun. Most of us stop working out because we aren?t having fun with the workout. Therefore, I wanted something entertaining that could be done in short increments. Most of our segments are 8-10 minutes, so if you can?t do the whole video, you can do a quick segment and you can come back to it. You can still get your workout on and get fit.?

CBS: How do you balance your busy career and family life?

PP: ?Well, it?s really about having effective time management. I think most women want to have it all, but sometimes it?s quite difficult to balance being a mom, being a wife, and having a successful career. At the end of the day it is all about scheduling and prioritizing.

You have to realize that you can?t do it all because no one can. You also have to be willing to ask for help. I think some of us moms get ?Super Mom Syndrome? and we really don?t want to ask for help when we need it. I don?t think there is anything wrong with saying, ?I need someone. I need a maid. I need someone to help me keep the house clean. I need someone to cook at least one day a week for me.?

At the end of the day, it?s about having a certain quality of life. To me, being a mother has more to do with being available to your child and having those moments that you can?t get back, such as reading the books, having the bath times, snuggling, and going to the park. That?s what?s important. I try to prioritize and make time for those moments, and I also try to ask for help when I need it. Sometimes it?s hard.?

CBS: How do you and your family plan to celebrate Earth Day? How do you teach your family to be eco-friendly?

PP: ?We are very into recycling. Earth Day is coming up so quickly and I can?t say that I?ve actually thought about it because I?ve just been running around like a chicken with my head cut off. I am sure we will try to find some projects where we can either recycle something or plant something, because I am teaching my son about planting and I?m really big on gardening.

I love to garden and lately we?ve been learning how to cook and how to take care of things. Earth Day might be a fun time for us to plant some of our pineapple tops and see what happens to them. I?ve been explaining to Ayden the purpose of seeds and fruits. More than likely we will plant something in our yard. We live in Georgia and now is a great time for planting because it is a little warm out and things will definitely grow.

I do try to teach my family to be eco-friendly. We recycle every week and we?ve got all our different bins. I try to teach my son about how plastics go into the different bins and about conserving, as much as you can teach a 2-year-old. He?s very much aware of plastics going in certain bins and the conservation of water. He?s also aware that if you don?t drink your bottled water, you put it in the plants and you try not to drink bottled water if you can get filtered water. He understands simple concepts like that.?

CBS: What do you have planned for Mother?s Day? What does Mother?s Day mean to you??

PP: ?That?s what my husband has to plan [laughs]. I need my day off for myself. He better have his plans ready, because that?s one day he?ll be on the hot seat [laughs].

I think every day should be Mother?s Day, because moms do so much. For moms, I think Mother?s Day is the one day you should be able to do whatever you like. It is such an honor to have a living mother, and you should have that day to celebrate her. My mom and I are very close and she?s pretty much already told me what she wants for Mother?s Day. I will hopefully celebrate with her during that weekend. It will be right around the time my son is due, so I?m sure I wont be doing too much because I will be ready to pop [laughs].?

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Source: http://www.celebritybabyscoop.com/2013/04/03/phaedra-pregnancy-going?utm_source=rss&utm_medium=rss&utm_campaign=phaedra-pregnancy-going

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