Friday, August 3, 2012

Mending a broken heart -- with a molecule that turns stem cells into heart cells

ScienceDaily (Aug. 2, 2012) ? For years, scientists have been looking for a good source of heart cells that can be used to study cardiac function in the lab, or perhaps even to replace diseased or damaged tissue in heart disease patients. To do this, many are looking to stem cells. Researchers at Sanford-Burnham Medical Research Institute (Sanford-Burnham), the Human BioMolecular Research Institute, and ChemRegen, Inc. have been searching for molecules that convert stem cells to heart cells for about eight years -- and now they've found one.

Writing in the August 3 issue of Cell Stem Cell, the team describes how they sifted through a large collection of drug-like chemicals and uncovered ITD-1, a molecule that can be used to generate unlimited numbers of new heart cells from stem cells.

"Heart disease is the leading cause of death in this country. Because we can't replace lost cardiac muscle, the condition irreversibly leads to a decline in heart function and ultimately death. The only way to effectively replace lost heart muscle cells -- called cardiomyocytes -- is to transplant the entire heart," said Mark Mercola, Ph.D., director of Sanford-Burnham's Muscle Development and Regeneration Program and senior author of the study. "Using a drug to create new heart muscle from stem cells would be far more appealing than heart transplantation."

Searching for a needle in a haystack

Stem cells are important because they do two unique things --

1) self-renew, producing more stem cells and

2) differentiate, becoming other, more specialized cell types.

To obtain a large number of a certain cell type, such as heart cells, the hard part is figuring out the signals that direct them to become the desired cell type.

Mercola's group has been hunting for heart-inducing signals for 15 years -- in embryos and in stem cells. To find a synthetic molecule that might one day lead to a drug therapy to regenerate the heart, they joined forces with a team of medicinal chemists at the Human BioMolecular Research Institute led by John Cashman, Ph.D. With funding from the California Institute for Regenerative Medicine, they used sophisticated robotic technology to methodically test a large collection of drug-like chemicals, looking for that needle in a haystack that, when added to stem cells, results in cardiomyocytes. The winning compound was ITD-1.

Therapeutic applications

There's no shortage of therapeutic possibilities for ITD-1. "This particular molecule could be useful to enhance stem cell differentiation in a damaged heart," explained Erik Willems, Ph.D., postdoctoral researcher in Mercola's lab and first author of the study. "At some point, it could become the basis for a new therapeutic drug for cardiovascular disease -- one that would likely limit scar spreading in heart failure and promote new muscle formation."

Mercola, Willems, and Cashman are now working with San Diego biotech company ChemRegen, Inc. to further develop ITD-1 into a drug that one day might be used to treat patients.

More scientific detail

The researchers discovered that ITD-1 blocks a cellular process known as TGF? signaling. TGF? (short for transforming growth factor-?) is a protein produced by one cell type to influence others' behaviors, such as proliferation, scarring, and even stem cell differentiation. TGF? works from outside the cell, binding to a receptor on the surface of a responding cell to initiate an intracellular signaling cascade that causes genes to be switched on or off, ultimately altering cellular behavior -- in this case making heart muscle.

ITD-1 triggers degradation of the TGF? receptor, thus inhibiting the whole process. With TGF? signaling turned off, stem cells are set on a course toward cardiogenesis. ITD-1 is the first selective inhibitor of TGF?, meaning that it might also have applications in many other processes controlled by TGF?.

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The above story is reprinted from materials provided by Sanford-Burnham Medical Research Institute, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Erik Willems, Joaquim Cabral-Teixeira, Dennis Schade, Wenqing Cai, Patrick Reeves, Paul?J. Bushway, Marion Lanier, Christopher Walsh, Tomas Kirchhausen, Juan?Carlos Izpisua?Belmonte, John Cashman, Mark Mercola. Small Molecule-Mediated TGF-? Type II Receptor Degradation Promotes Cardiomyogenesis in Embryonic Stem Cells. Cell Stem Cell, 2012; 11 (2): 242 DOI: 10.1016/j.stem.2012.04.025

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://www.sciencedaily.com/releases/2012/08/120802122459.htm

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Thursday, August 2, 2012

Class of 2012: Europe's young pursue dreams abroad

FOR STORY : CLASS OF 2012 - BRAIN DRAIN : In this 19 June 2012 picture Rafael Gonzalez del Castillo, architecture student looks through one of his architecture models at his home in Madrid before being interviewed by The Associated Press. "I see myself working abroad,? said Gonzalez del Castillo, ?It doesn't matter where." According to economist at Madrid's IE Business School, Gayle Allard, the long-term toll of emigration could be sinking competitiveness as crisis-hit countries lose many of their best and brightest citizens a potential formula for a vicious circle of economic agony, although they could benefit if young emigres return, bringing back better work and language skills. (AP Photo/Daniel Ochoa de Olza)

FOR STORY : CLASS OF 2012 - BRAIN DRAIN : In this 19 June 2012 picture Rafael Gonzalez del Castillo, architecture student looks through one of his architecture models at his home in Madrid before being interviewed by The Associated Press. "I see myself working abroad,? said Gonzalez del Castillo, ?It doesn't matter where." According to economist at Madrid's IE Business School, Gayle Allard, the long-term toll of emigration could be sinking competitiveness as crisis-hit countries lose many of their best and brightest citizens a potential formula for a vicious circle of economic agony, although they could benefit if young emigres return, bringing back better work and language skills. (AP Photo/Daniel Ochoa de Olza)

FOR STORY : CLASS OF 2012 - BRAIN DRAIN : This made available by Maria Adele Carrai, shows Maria in an undated image. Maria Adele Carrai, 26, got her bachelor?s degree in Chinese language and culture in Rome, graduating at the top of her class, and went on to complete a master?s in Venice focusing on Asian languages, economics and legal institutions. When she finished, she could find only low-paying work as an Italian-Chinese translator for a court that always paid her late, or not at all and she has done freelance translation work on the side, making euro5 ($6) per hour. According to economist at Madrid's IE Business School, Gayle Allard, the long-term toll of emigration could be sinking competitiveness as crisis-hit countries lose many of their best and brightest citizens a potential formula for a vicious circle of economic agony, although they could benefit if young emigres return, bringing back better work and language skills.(AP Photo)

(AP) ? Santiago Oviedo, a lanky 24-year-old from Madrid, is on track to get his master's in physics in October ? a crucial milestone in his dream of becoming a researcher probing the origins of the universe.

Spain won't benefit from his big brain.

Because of education spending cuts and Spain's downward economic spiral, Oviedo is planning to emigrate to Britain, France, the Netherlands or Germany to get his Ph.D. or work at a company that lets him do research. He's afraid he may never work or raise a family in his country.

If he had graduated two years ago, Oviedo would have stood a good chance of landing a government-funded scholarship and grant for four years of doctoral study and research. That has evaporated in an austerity drive that has brought slashed budgets for scientific research and waves of layoffs at companies large and small.

With Spain's unemployment rate for people under 25 at an astonishing 53 percent, young Spaniards are leaving the country in droves to carve out a brighter future. Most seek jobs, but some, like Oviedo, are leaving because the government is struggling to afford to develop their minds.

Since 2009, when Europe's financial crisis hit full-bore, the number of Spaniards in their late teens, 20s and early 30s leaving the country has increased 52 percent ? from about 12,500 to nearly 20,000 according to the government statistics agency. Young and talented Europeans from other hurting eurozone nations ? Greece, Ireland, Italy and Portugal ? are also abandoning home not only for stronger European countries but surging former European colonies in Africa, Asia and the Americas.

___

Editors: This is the latest installment in Class of 2012, an exploration of Europe's financial crisis through the eyes of young people emerging from the cocoon of student life into the worst downturn the continent has seen since the end of World War II.

___

Oviedo is set to join a growing number of young Spaniards giving up on Spain, a nation that had visions of grandeur during a decade-long property boom but which is now teetering on the edge of financial collapse.

"I don't want to go away forever, but looking at the situation how it is now, maybe that will happen," said Oviedo, who heads to every Madrid anti-austerity protest he can fit in with his studies. He blames politicians for immersing Spain in its misery.

In addition to education spending cuts, Spain last December eliminated its Ministry of Science and Innovation to save money, making it a division of the Economy Ministry. In May, the country saw a tide of protests against the education squeeze by university students and teachers, some of whom clashed with police.

"Science isn't a priority now in Spain," Oviedo said. "The economy is terrible. A couple years ago we had a really good public health and education system, but now they are destroying it all. When I have children, I don't want them to live here if they don't have the things I have enjoyed."

Oviedo's fears mirror those of Spanish architecture student Rafael Gonzalez del Castillo, one of the five European students whose lives The Associated Press is tracking in the Class of 2012 project.

"I see myself working abroad," said Gonzalez del Castillo, as do many of his 25 architecture classmates at his elite Madrid university. "I don't know where. It doesn't matter where."

The long-term toll could be sinking competitiveness as crisis-hit countries lose many of their best and brightest amid already falling birth-rates ? a potential formula for a vicious circle of economic agony. But countries like Spain could benefit if young emigres return because they would bring back better work and language skills that would help fix low productivity, said Gayle Allard, an economist with Madrid's IE Business School.

"If they come back it will be for the good of the country," said Allard. "If they don't come back, this is a tragedy,"

Across the border from Spain, the number of Portuguese heading to former colonies Brazil and Angola for work has increased sharply since 2008. The trend has accelerated since last year when Portugal got a bailout of its public finances, according to statistics based on consulate and embassy registrations. Portugal's prime minister suggested last year that unemployed teachers should consider heading to former colonies for work. The country doesn't track youth emigration, but researchers say it is rising.

One of Gonzalez del Castillo's friends is a 26-year-old Spanish civil engineer who graduated last October, and moved to Brazil last month after a six-month job hunt in Spain that netted not a single job interview. She represents a sharp reversal for countries like Spain and Portugal, which for decades were on the receiving end of migrants from Latin America.

She has already had better luck in the booming business hub of Sao Paulo, getting an interview within two weeks of arriving. The woman did not want her name revealed because she entered Brazil on a tourist visa and fears she could be deported if caught seeking work.

In bailed-out Ireland, emigration has become a defining national characteristic. More than 76,000 people left last year, representing 1.7 percent of the population. They joined 200,000 who have departed since 2008 at the end of a property boom-gone-bust similar to Spain's. Their top destinations are Britain, Australia, Canada and the United States. Official statistics show that the vast majority of those leaving are in their 20s and 30s.

Orla Kelleher, executive director of the Aisling Irish Community Center in Yonkers, New York, said the volume of newly arrived Irish jobseekers had multiplied six times "if not more" since 2009, following the implosion of the Celtic Tiger economy.

Brian Whelan, 28, moved to London from Dublin two years ago after being recruited to work on the Irish pages of the Yahoo news site. Many of his Dublin friends are living outside the country, many in Canada.

"If I hadn't landed a job in advance I'd have been heading to London anyway," said Whelan, who now works as a freelance journalist. "Irish people are not having any difficulty landing jobs abroad. It's often the best and the brightest who are going abroad. Some of the best trained and most able young people are leaving because Ireland can't afford to keep them."

Italy, whose decaying economy may soon need a bailout, has long been bleeding much of its finest talent as rigid labor laws and chronic cronyism force highly skilled young people abroad. Italy doesn't track how many citizens leave, but the country's statistics agency said the number of Italians with college degrees living abroad rose from 8.3 percent in 2001 to 15.9 percent in 2010.

Maria Adele Carrai, 26, got her bachelor's degree in Chinese language and culture in Rome, graduating at the top of her class, and went on to complete a master's in Venice focusing on Asian languages, economics and legal institutions. When she finished, she could find only low-paying work as an Italian-Chinese translator for a court that always paid her late ? or not at all. She did freelance translation on the side, making ?5 ($6) an hour.

Carrai would rather be home but left Italy for Hong Kong, where she's doing her Ph.D.

"That's the only way to become economically independent," she said. "Italy is an unthinkable destination right now."

Oviedo, the physics master's candidate, thinks he would probably be able to land a well-paid job in Madrid, where large banks pay good money for math whizzes like him to be analysts, known as "quants," and design complex trading formulas.

Oviedo says he would hate himself if he used his math skills to help big banks profit off the financial crisis.

"I don't want to do that job. It would be like helping the enemy," he said. "They have destroyed the world. I see the results every day in Spain."

___

Associated Press writers Paola Barisani in Rome, Derek Gatopoulos in Athens, Shawn Pogatchnik in Dublin and Daniel Woolls in Madrid contributed to this report.

___

Follow The Class of 2012 on the AP Big Story page:

http://bigstory.ap.org/topic/class-2012

___

Follow The Class of 2012 on Twitter:

https://twitter.com/#!/AP/class-of-2012

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/cae69a7523db45408eeb2b3a98c0c9c5/Article_2012-08-01-Class%20of%202012-Brain%20Drain/id-0d24ca8a685840518aa810c4fa087e81

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Ahead of the Bell: True Religion Apparel

NEW YORK (AP) -- Shares of True Religion Apparel Inc. plummeted nearly 15 percent before the market open on Wednesday as the clothing company's second-quarter revenue performance missed Wall Street's expectations. It also cut its full-year earnings guidance and lowered the high end of its revenue outlook.

Late Tuesday True Religion, which is known for its high-end jeans, reported that its quarterly revenue rose 7 percent to $104.9 million from $98.3 million, but the results were short of the $107.4 million that analysts polled by FactSet predicted.

Ronald Bookbinder of Benchmark said in a client note that the company's problems occurred at its full-price stores as new, simpler styles that were priced higher than its rivals' offerings did not sell well.

The analyst lowered True Religion's price target to $32 from $38 and reiterated a "Buy" rating.

Citing its quarterly performance and current market conditions, True Religion lowered its full-year earnings forecast to a range of $1.80 to $1.86 per share. It previously expected $1.88 to $1.95 per share.

True Religion also reduced the high end of its revenue guidance. The company now anticipates revenue between $450 million and $455 million. Its prior outlook called for revenue between $450 and $460 million.

Wall Street is looking for earnings of $1.97 per share on revenue of $467.1 million.

Citi Investment Research's Susan Anderson dropped True Religion's price target to $27 from $29. The analyst said that the Vernon, Calif., company revised its full-year guidance because of slower growth in U.S. retail sales and abroad.

Anderson says the outlook now seems "conservative enough to account for weaker international results and more modest U.S. spending."

The analyst kept a "Neutral" rating.

True Religion's stock fell $3.90, or 14.9 percent, to $22.34 in premarket trading.

Source: http://news.yahoo.com/ahead-bell-true-religion-apparel-132452069.html

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Teachers Write 8/2 Thursday Quick-Write

Good morning, everyone!? I?m traveling this week into next week ? first to the annual Society of Children?s Book Writers & Illustrators Conference in Los Angeles, where I?ll give a workshop on ?The Magical Unexpected? in picture books and speak at the Golden Kite Awards Luncheon celebrating OVER AND UNDER THE SNOW and the other winners.? I?ll fly from there to the Millersville Writing Institute in Pennsylvania, where I?m presenting on writing and revision (and looking forward to spending time with amazing teacher-writers!) And then it?s on to St. Louis, where I?m speaking at a Scholastic Book Fairs event because CAPTURE THE FLAG and EYE OF THE STORM will both be featured in the fall book fairs, which delights me to no end.

Don?t worry ? all your assignments and quick-writes and everything else are scheduled and will appear as if by magic on the right days, even while I?m gone. But I will be checking in more sporadically than usual and wanted to let you know that I haven?t dropped off the face of the earth.? I?m probably just stuck in some airport with a dead laptop battery.

Anyway?you will have some great guest authors in my absence, starting with Kristy Dempsey today!? Kristy is a teacher, picture book author, and poet whose books include MINI-RACER (Bloomsbury), ME WITH YOU (Philomel), and SURFER CHICK (Abrams). Her website is http://www.kristydempsey.com/

At the end of this school year the first graders were studying the elements of story through fairy tales. We talked about imagination, we talked about the cultural aspects of fairy tales from around the world, we talked about what gave these characters believable qualities even though the stories themselves might have magical elements.

Toward the end of our unit we watched the film, ?A Little Princess?. I was rather amazed as the first graders identified that Sara?s locket and the importance it held for her made the story feel believable to them. One student even said, ?It?s like her locket held everything her daddy had ever given her and when Miss Minchin took it away from her, Sara knew she still had all that in her heart.? These first graders understood the importance of emotional truth!

Think of the physical item that is most important to your main character. What does it represent? Now, imagine it being lost or taken away from your main character. How would he/she respond? Sara Crewe?s response, of course, was fairly noble. But what if your character pitched a fit? Or what if he/she embarked on a series of misadventures to try to recoup what was lost? (In fact, one of the funniest scenes in the movie is when Sara?s friends enter Miss Minchin?s office to try to get the locket back.)

Write a scene that shows the emotional importance of this physical item to your main character and then show us how he/she responds when it is lost or taken. I can?t wait to read the serious or funny or fantastical emotionally true scenes you come up with!

Source: http://www.katemessner.com/teachers-write-82-thursday-quick-write/

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Wednesday, August 1, 2012

Weddings Ain't For Weenies - Marriage Confessions

This post is the second installment of a series of posts that tell the story of my seven year marriage.? Hope you enjoy reading it as much as I enjoyed living it?

***********

We got married too young. My parents knew it.? His parents knew it.? I knew it.? Chris knew it.? Everyone knew it.? At our wedding reception, our first dance was to Elvis Presley?s Fools Rush In.? ?Wise men say, only fools rush in, but I can?t help falling in love with you.?? That was us.? Fools.? Fools completely in love with each other.? Fools who had grown up together ? who were still growing up together.? Fools who were too foolish to know that we didn?t know the first thing about being married.? But fools who couldn?t take another step forward in life without having the other fool by their side.? That was us.? Just a couple of fools.

Though it surprises some people that Chris and I are still happily married seven years later (pools by our high school friends had us clocking out at two years?) the miracle to me is not that we are still married, but that we ever made it to the alter to begin with.? Chris was what you would call a?let?s see?how can I put this delicately?? He was a man-whore.? Yes, a high-school aged, hormone crazed, charming the pants literally right off of girls, man whore.?? And I was in student government, youth ambassador at my church, and part of an abstinence education program in the public school systems.? We were polar opposites from the very beginning, though I am happy to report that like a good barrel of wine, our flavors have married together over the years and we seem to be a nice, robust blend now.? But back then, we were a whirlwind of drama that would make any teenage vampire/werewolf/wizard novel of today look like Sweet Valley High.

Even at the age of fifteen, I saw something in Chris.? I saw that he went home for dinner with his Dad and sister every single night, no matter what was going on and that told me that he, like me, put family first.? I saw him spend summers working with middle school kids at camps and that told me that he, like me, made giving back a priority.? I saw him skipping classes but only so that he could spend more time building theater sets (which he would later do professionally for Broadway) and that told me that he, like me, was driven and focused.? Even though Chris was a man whore whose high school parties were infamous for underage drinking and?everything that goes along with underage drinking?we actually had a lot in common.? And we had the things in common that counted.

IMG_2490

And so, I waited.? I waited for Chris to grow up.? And when he made mistake after countless mistake, I still waited because I knew that mistakes were just part of his growing up process and I could see that he truly cared enough to learn from those mistakes.? And because I waited for him, he fell in love with me not because of what I brought to his life, but because I saw the value of what he brought to mine.? I think that was my first lesson in love.? It?s not about what one person does for the other person, it is about what you can do together for each other.

So, with that in mind, we graduated from high school with the scars of adolescent heartbreak on our sleeves and we headed off to separate colleges, agreeing to stay together until one of us found someone else.? No big promises.? Just the love of our high school sweetheart as the baseline for any other relationship to surpass.? And over the four years we were in school, nothing ever surpassed what Chris and I had.? We spent those years traveling back and forth to see each other every couple weekends.? We sent love notes and spent God knows how much money on cell phone bills.

Our junior year of college, Chris and I took a Christmas vacation, just the two of us, to New York. Neither of us had ever been to New York before.? I look back now at pictures from the two of us on that trip and we look like such babies.? Like we had to take cabs everywhere because we may not actually be old enough to drive ourselves.? That young.? But isn?t that what they say?? New York is for young lovers?

No?? They don?t say that?

Well, they should.

We spent a week exploring the Big Apple like the two wide-eyed small town tourists that we were. On our last night in New York, Chris and I went to see The Rockettes in Radio City Hall.? Classic New York.? I was in love that night.? In love with the lights of the city.? In love with the sound of the Salvation Army bells ringing on the sidewalks. ?In love with the dancers in their soldier costumes.? And in love with the boy who was sitting next to me.? All was right with the world.

Chris would later tell me that the platinum band in his pocket set off the metal detectors as he entered Radio City with me that night.? When the security guard patted him down and found the little red box tucked into his jacket pocket, he patted him on the back, gave him a wink and a big smile, and said, ?Enjoy your evening, Sir.?

After the show, Chris and I walked down to Rockefeller Center and Chris asked if I wanted to ice skate.? I squealed as we tied on our ice skates and took to the ice.? As we skated hand-in-hand, Chris talked about what a great time he had had on our trip.? He talked about what fun experiences and adventures we had had so far together, about fun things we?d done and crazy stories that build up only when you?ve been together since you were children.? And then he stopped skating and turned to face me on the ice.? Right there in under the lights of the enormous Christmas tree, he got down on one knee.

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?The life that we?ve already shared together isn?t enough for me.? I need more than that,? he said, pulling the ring box out of his jacket and holding the most beautiful diamond solitaire out to me.? ?Will you marry me??

I said yes and jumped into his arms, just as the crowds of tourists looking down from above started cheering for us.? It was, and still is, the most magical moment of my entire life.

The wedding would be over a year later on June 4, 2005.? The doors of the church opened and there at the end of that long aisle, stood my groom.? The love of my young life.? And I remember thinking how fitting it was to walk down the aisle of a church where I had grown up and into the arms of the man that I had grown up with.? He looked handsome.? And terrified.? And incredibly happy.? And as I walked down that aisle, we never took our eyes off of each other.

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???|???posted in Book, Changes, Childhood, Flashbacks, Marriage, Marriage Confessions, Weddings???|???tags: high school sweethearts, love, Marriage, Relationships, Weddings

Source: http://marriageconfessions.com/2012/08/01/weddings-aint-for-weenies/

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Patient tools to assist decision-making about PSA tests for risk of ...

Posted on by Sitemaster

As previously discussed on this blog, on July 16 the American Society?of Clinical Oncology (ASCO) issued a provisional clinical opinion or PCO on the merits of screening for prostate cancer (see prior commentary on this PCO).

ASCO has now, in addition, released two associated items specifically designed to assist individual patients to make?appropriate decisions about whether they do or do not want to get PSA tests:

It seems likely that not everyone is going to agree with the content of these two documents because a lot depends on personal interpretation of the data on which these two documents are based. However, The ?New? Prostate Cancer InfoLink believes that these will be helpful materials for those patients who want to be able to make good decisions about the value of PSA testing for themselves as individuals (as opposed to letting others make decisions for them).

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Source: http://prostatecancerinfolink.net/2012/08/01/patient-tools-to-assist-decision-making-about-psa-tests-for-risk-of-prostate-cancer/

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Online poker companies settle with U.S.; two to combine

NEW YORK (Reuters) - Two online poker companies settled U.S. civil charges of illegal Internet gambling on Tuesday in a deal that positions one of them to take over the assets of the other and to capitalize on the growing legalization of the U.S. market.

The Department of Justice said it had brokered a deal in which Isle of Man-based PokerStars will acquire the assets of rival Full Tilt of Dublin and forfeit $731 million. The two companies, once the main online poker operators in the United States, along with a third, Absolute Poker, were slapped with civil money laundering charges last year.

The PokerStars forfeiture comprises $547 million payable over three years to reimburse Full Tilt customers in the United States, as well as $184 million representing all outstanding balances owed to non-U.S. customers of Full Tilt, prosecutors said in a statement.

The companies did not admit wrongdoing in the settlement.

Mark Scheinberg, PokerStars' chairman, said in a statement that the company was "delighted" to resolve the case.

Criminal charges against individual owners and employees of the gaming companies will continue. In April 2011, prosecutors accused 11 owners and employees of the three companies of tricking regulators and banks into processing billions of dollars of illegal Internet gambling proceeds.

Prosecutors on Tuesday also announced they had entered into a proposed settlement with Absolute Poker, which called for it to forfeit assets to the government. That deal must be approved by U.S. District Judge Leonard Sand in Manhattan, who has overseen the civil cases against the three companies.

Tuesday's civil settlements come as Delaware in July became the second state to authorize licensed online poker within its borders, following Nevada, which is now reviewing license applications.

Many cash-starved states, encouraged by intensive industry lobbying, have felt freer to act since December, when the Justice Department declared that one federal anti-gambling law, the Wire Act, would no longer be enforced beyond sports betting.

(Additional reporting By Joseph Menn in San Francisco and Jonathan Stempel in New York; Editing by Martha Graybow, Maureen Bavdek and Tim Dobbyn)

Source: http://news.yahoo.com/online-poker-companies-settle-u-two-combine-182628349--sector.html

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